With pets in your home, accidents can happen anytime. Especially with puppies, senior dogs, cats, or pets still learning. The real problem isn’t the mess they leave but the odor that never quite goes away.
Dog and cat urine can easily soak into carpets, leaving behind strong odors and visible stains. If your carpets are leaving a urine smell, your pets will prefer to use them more often for pee. So, it’s important to keep your carpets clean and odor-free all the time.
To tackle this situation, you need the best enzyme cleaner. Most regular cleaners are not able to clean dried pet urine. This results in stains and urine odor. Dog urine contains proteins and uric acid crystals that soak deep into carpet fabrics and flooring. Standard cleaners don’t break it down. That’s why we recommend getting a good enzyme cleaner. These cleaners utilize enzymes and bacteria to break down and digest organic matter, such as stains, odors, and waste, making them effective.
We have tested many carpet cleaner solutions to make it easy for you to decide. In this post, we’ll help you find the best enzyme cleaners for dog and cat urine that actually work. Whether it’s on carpet, hardwood, or a rug, these cleaners are designed to eliminate stains and odors for good.
Our Top Picks:
Rocco & Roxie Stain & Odor Eliminator
Reasons to buy:- Safe to use around pets and children
- Can be used on carpets, floors, furniture, or clothing
- Contains natural enzymes that are activated on contact
Bissell Professional Stain & Odor
Reasons to buy:- Removes difficult stains like motor oil, pet soils & blood
- Removes tough odors
- Works on carpets, upholstery and mattresses
Simple Solution Extreme Cleaner
Reasons to buy:- Comes with a budget price tag
- Eliminates scents that attract pets back to the same spot
- Safe for use around pets and children
Nature’s Miracle Urine Destroyer Plus
Reasons to buy:- Break down and remove stains immediately on contact
- Safe for use around pets and children
- Works on carpets, upholstery and mattresses
Biokleen Bac-Out Enzyme Stain & Odor
Reasons to buy:- Safely works wonders on pet accidents
- Preferred choice of commercial carpet cleaners
- Plant-based, eco-friendly solution with no dyes
Angry Orange Stain Remover
Reasons to buy:- Best smelling cleaner
- Dual anti-tangle design
- Smart navigation with precise LiDAR
Rocco & Roxie Enzyme Cleaner
This one’s my personal go-to, and honestly, it’s saved me more times than I can count. The first time I tried Rocco & Roxie, I had a senior dog who’d started having more accidents. The stain was old, and the smell was pretty set in. I sprayed the area generously and let it sit for 10–15 minutes before blotting it out. I was shocked. It completely removed the odor, and even the yellowish stain faded away after one more treatment. It works wonders on carpet and upholstery.
That said, the nozzle sometimes sprays unevenly, and it’s a bit pricier than other options. But for the peace of mind it gives me, I honestly think it’s worth every penny. One more thing I love is that it’s safe for both pets and kids, so I don’t have to worry about anyone walking on the area afterward. Overall, a solid performer I keep stocked at all times.
Reasons to buy:
- Very effective on old stains and odors
- Safe for pets and children
- Works well on carpet and upholstery
Reasons to avoid:
- Nozzle spray can be uneven
- Slightly more expensive than other options
Bissell Professional Stain & Odor
I tried this one during a hectic week when my dog had a stomach bug, and I was cleaning up multiple messes daily. Bissell’s Professional formula comes in a large bottle and has a pleasant scent, not too strong, but clean enough to mask any lingering smells during the cleaning process. It worked pretty quickly on fresh stains, and I didn’t have to do much scrubbing.
What I don’t love is that it struggles with older stains. I tried it on an old pee spot on a hallway carpet, and while the smell was reduced, the stain still needed a second pass. On the plus side, it’s enzyme-based, affordable, and you get a good quantity for the price. It’s also great if you’re using a carpet cleaner machine; it foams up well and doesn’t leave a sticky residue.
Reasons to buy:
- Great for fresh stains
- Works well with carpet cleaning machines
- Large quantity for the price
Reasons to avoid:
- Less effective on old, set-in stains
- Scent may not be strong enough for tough odors
Simple Solution Extreme Cleaner
This one really surprised me. I picked it up on a whim when it was on sale, and now it’s one of my favorites. Simple Solution Extreme comes with a special 3-in-1 nozzle (mist, foam, stream), and I found that especially helpful for different surfaces. For example, I use the mist on fabrics and the stream on tile floors. It works fast, and the enzyme formula is quite strong.
The downside is the strong chemical scent right after use. I had to leave windows open for a bit because of it. However, it completely removes odor and stains, even from hardwood (just test a small area first). I’d recommend this if you’ve got multiple pets or are dealing with repeated accidents; it’s industrial strength, and it shows.
Reasons to buy:
- 3-in-1 nozzle is versatile
- Industrial strength performance
- Works on various surfaces including hardwood
Reasons to avoid:
- Strong initial chemical smell
- Not ideal for those sensitive to scents
Nature’s Miracle Urine Destroyer Plus
Nature’s Miracle has a big name, and I had high expectations. I’ve used the standard formula before and wasn’t very impressed, but the Urine Destroyer Plus version? That’s a game changer. I had a stubborn pee spot that every other cleaner had failed to fully fix. This one lifted the smell completely.
However, you need to be patient. It needs to sit for a while to really break things down. I usually give it a full 30 minutes. I also noticed that if I didn’t blot it well enough, it left a bit of stickiness. Still, it works great on carpets and rugs, and it’s one of the few I trust to actually work long-term. Bonus: it leaves a clean citrus scent that doesn’t smell like chemicals.
Reasons to buy:
- Strong formula for tough stains
- Pleasant citrus scent
- Reliable for long-term odor control
Reasons to avoid:
- Needs longer soak time
- Can leave a sticky residue if not blotted well
Biokleen Bac-Out Enzyme Cleaner
If you’re looking for something a little more eco-friendly, Biokleen Bac-Out is the way to go. I first tried this when I started paying more attention to using natural products around my pets. It’s plant-based, non-toxic, and has a nice lime scent. Surprisingly, it’s effective at neutralizing odors from pet urine.
That said, it doesn’t work as quickly as some of the harsher chemical options. I usually let it soak longer than usual, around 20–30 minutes, especially on thicker rugs. But once it’s done, the smell is completely gone, and I feel better knowing there aren’t harsh residues left behind. Perfect if you have small children or pets that lick the floor.
Reasons to buy:
- Eco-friendly and plant-based
- Safe for kids and pets
- Fresh lime scent
Reasons to avoid:
- Takes longer to work on thick carpets
- Less powerful on very old stains
Angry Orange Stain Remover
I bought Angry Orange after seeing it hyped on social media and I get the hype now. The orange scent is so refreshing compared to the usual “cleaner” smell, and it made the whole room smell great. I used it on both carpet and hardwood, and it didn’t damage anything. In fact, it made my house smell like I’d just deep cleaned it.
That said, the sprayer head was a little finicky, and I had to switch bottles. Also, it’s better for fresh messes than old ones. On a week-old pee stain, I had to treat the area twice. But the trade-off is worth it for the fragrance and the natural-based ingredients. If you like citrus scents and want something that actually masks smell while cleaning, this is a great pick.
Reasons to buy:
- Refreshing orange scent
- Works on multiple surfaces
- Natural-based ingredients
Reasons to avoid:
- Sprayer can be faulty
- Less effective on old stains
Final Thoughts
Finding the right enzyme cleaner can make a world of difference in managing pet messes and keeping your home smelling fresh. Through my personal experience with these cleaners, I’ve realized that not every product works the same for every surface or situation. Some are better for quick, fresh stains, while others shine in dealing with old, stubborn spots. If I had to pick one all-around favorite, it would be Rocco & Roxie for its power and reliability. The others also serve specific needs really well.
Ultimately, the best enzyme cleaner is the one that fits your lifestyle, pet habits, and cleaning preferences. Whether you want something eco-friendly, budget-friendly, or industrial-strength, there’s something here that works. I hope my honest take on these products helps you make the right call—and keeps your home as clean and odor-free as possible!